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Exhibits antiproliferative activity in cancer cells in vitro (IC50 values are 400 and 700 nM for HCT116 and HeLa cells respectively). Activates the unfolded protein response (UPR) and modulates autophagosome maturation. It has not been cleared or approved by the US Food and Drug Administration. Selective over all other AAA ATPases, HSP90 and kinases tested (IC50 >10 muM). This test was developed and its performance characteristics determined by NMS Labs. Potent p97 ATPase (VCP) allosteric inhibitor (IC50 = 30 nM). Potent and selective p97 ATPase (VCP) allosteric inhibitor Tocris Bioscience 6180 IC50 value: 20 nM (Wild Type VCP, 1 mM ATP) Target: VCP/p97 in vitro: In standard assay conditions, NMS-873 had an IC50 of 30 nM, which was unchanged at saturating ATP concentration. NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with IC50 value of 20 nM (Wild Type, 1 mM ATP).
#Nms chlorine manuals#
He worked on the first intercontinental missile, wrote instruction manuals for the first vacuum tube computers, worked on secret radio control electronics, and dozens of other “state of the art” electronic projects at Hughes Aircraft Company, Northrop Aircraft, General Motors Research Defense Laboratories, and others.Īfter 20 years in the Aerospace Industry, Jim went into gold mining where he developed methods of gold recovery that replace the use of mercury to help overcome health issues for small miners.
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Jim first started his career in the Aerospace industry, where he quickly became a research engineer. He has authored many successful books and his current developments are outlined in this instruction guidebook. Over the years Jim has maintained his interest in alternative health, and worked with numerous healing modalities including healing his own broken neck in record time using magnets. The test was later computerized and was considered by many to be the most accurate method of determining deficiencies known at the time. He authored a 200 question “Nutritional Evaluation Test” that determined the vitamins, minerals, proteins, and fats a person’s body might be deficient in. Jim Humble first began his work in the health field in his early 20’s when he became the manager of a health food store in Los Angeles, California.